Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation and to attenuate trabecular cardiomyocyte proliferation

BACKGROUND: Trabeculation is an integral component of cardiac ventricular morphogenesis and is dependent on the matrix metalloproteinase, ADAMTS1. A substrate of ADAMTS1 is the proteoglycan versican which is expressed in the developing ventricle and which has been implicated in trabeculation. Fibuli...

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Main Authors: Cooley, Marion A., Fresco, Victor M., Dorlon, Margaret E., Twal, Waleed O., Lee, Nathan V., Barth, Jeremy L., Kern, Christine B., Iruela-Arispe, M. Luisa, Argraves, W. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489172/
https://ncbi.nlm.nih.gov/pubmed/22183742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.23716
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