Neurosteroid Analogues. 15. A Comparative Study of the Anesthetic and GABAergic Actions of Alphaxalone, Δ(16)-Alphaxalone and Their Corresponding 17-Carbonitrile Analogues

Alphaxalone, a neuroactive steroid containing a 17β-acetyl group, has potent anesthetic activity in humans. This pharmacological activity is attributed to this steroid’s enhancement of γ-amino butyric acid-mediated chloride currents at γ-amino butyric acid type A receptors. The conversion of alphaxa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bandyopadhyaya, Achintya K., Manion, Brad D., Benz, Ann, Taylor, Amanda, Rath, Nigam P., Evers, Alex S., Zorumski, Charles F., Mennerick, Steven, Covey, Douglas F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965472/
https://ncbi.nlm.nih.gov/pubmed/20875742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados