A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells

Maize ribosome-inactivating protein (RIP) is a plant toxin that inactivates eukaryotic ribosomes by depurinating a specific adenine residue at the α-sarcin/ricin loop of 28S rRNA. Maize RIP is first produced as a proenzyme with a 25-amino acid internal inactivation region on the protein surface. Dur...

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Bibliographische Detailangaben
Hauptverfasser: Law, Sue Ka-Yee, Wang, Rui-Rui, Mak, Amanda Nga-Sze, Wong, Kam-Bo, Zheng, Yong-Tang, Shaw, Pang-Chui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Synthetic Biology and Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965250/
https://ncbi.nlm.nih.gov/pubmed/20558598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq551
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