Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization

The RNaseIII enzyme Drosha plays a pivotal role in microRNA (miRNA) biogenesis by cleaving primary miRNA transcripts to generate precursor miRNA in the nucleus. The RNA binding and enzymatic domains of Drosha have been characterized and are on its C-terminus. Its N-terminus harbors a nuclear localiz...

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Bibliografiske detaljer
Main Authors: Tang, Xiaoli, Zhang, Yingjie, Tucker, Lynne, Ramratnam, Bharat
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965249/
https://ncbi.nlm.nih.gov/pubmed/20554852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq547
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