The RNase III Enzyme DROSHA Is Essential for MicroRNA Production and Spermatogenesis

DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of canonical miRNAs. DICER is a cytoplasmic RNase III enzyme that not only cleaves precursor miRNAs to produce mature miRNAs but also dissects natur...

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Detalhes bibliográficos
Main Authors: Wu, Qiuxia, Song, Rui, Ortogero, Nicole, Zheng, Huili, Evanoff, Ryan, Small, Chris L., Griswold, Michael D., Namekawa, Satoshi H., Royo, Helene, Turner, James M., Yan, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408133/
https://ncbi.nlm.nih.gov/pubmed/22665486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.362053
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