Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination

The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expres...

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Main Authors: Tang, Xiaoli, Wen, Sicheng, Zheng, Dong, Tucker, Lynne, Cao, Lulu, Pantazatos, Dennis, Moss, Steven F., Ramratnam, Bharat
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757024/
https://ncbi.nlm.nih.gov/pubmed/24009686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072503
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