Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination

The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expres...

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Detalhes bibliográficos
Main Authors: Tang, Xiaoli, Wen, Sicheng, Zheng, Dong, Tucker, Lynne, Cao, Lulu, Pantazatos, Dennis, Moss, Steven F., Ramratnam, Bharat
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757024/
https://ncbi.nlm.nih.gov/pubmed/24009686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072503
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