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Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination
The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expres...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3757024/ https://ncbi.nlm.nih.gov/pubmed/24009686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072503 |
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