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Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination

The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expres...

詳細記述

保存先:
書誌詳細
主要な著者: Tang, Xiaoli, Wen, Sicheng, Zheng, Dong, Tucker, Lynne, Cao, Lulu, Pantazatos, Dennis, Moss, Steven F., Ramratnam, Bharat
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757024/
https://ncbi.nlm.nih.gov/pubmed/24009686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072503
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