Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination

The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expres...

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Bibliografski detalji
Glavni autori: Tang, Xiaoli, Wen, Sicheng, Zheng, Dong, Tucker, Lynne, Cao, Lulu, Pantazatos, Dennis, Moss, Steven F., Ramratnam, Bharat
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757024/
https://ncbi.nlm.nih.gov/pubmed/24009686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072503
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