Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization

The RNaseIII enzyme Drosha plays a pivotal role in microRNA (miRNA) biogenesis by cleaving primary miRNA transcripts to generate precursor miRNA in the nucleus. The RNA binding and enzymatic domains of Drosha have been characterized and are on its C-terminus. Its N-terminus harbors a nuclear localiz...

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Bibliographic Details
Main Authors: Tang, Xiaoli, Zhang, Yingjie, Tucker, Lynne, Ramratnam, Bharat
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965249/
https://ncbi.nlm.nih.gov/pubmed/20554852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq547
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