Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26

HDM2 is a p53-specific E3 ubiquitin ligase. Its overexpression leads to excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. HDM2 also affects the cell cycle, apoptosis and tumorigenesis through interacting with other molecules, including several ribosomal proteins...

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Autors principals: Zhang, Ying, Wang, Jian, Yuan, Yanzhi, Zhang, Wanqiao, Guan, Wei, Wu, Zhihao, Jin, Chaozhi, Chen, Hui, Zhang, Lingqiang, Yang, Xiaoming, He, Fuchu
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965247/
https://ncbi.nlm.nih.gov/pubmed/20542919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq536
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