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The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression

The control of messenger RNA (mRNA) function by micro RNAs (miRNAs) in animal cells requires the GW182 protein. GW182 is recruited to the miRNA repression complex via interaction with Argonaute protein, and functions downstream to repress protein synthesis. Interaction with Argonaute is mediated by...

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Detalhes bibliográficos
Main Authors: Chekulaeva, Marina, Parker, Roy, Filipowicz, Witold
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965232/
https://ncbi.nlm.nih.gov/pubmed/20530530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq501
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