Safety and Immunogenicity of a Replication-Defective Adenovirus Type 5 HIV Vaccine in Ad5-Seronegative Persons: A Randomized Clinical Trial (HVTN 054)

BACKGROUND: Individuals without prior immunity to a vaccine vector may be more sensitive to reactions following injection, but may also show optimal immune responses to vaccine antigens. To assess safety and maximal tolerated dose of an adenoviral vaccine vector in volunteers without prior immunity,...

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Main Authors: Peiperl, Laurence, Morgan, Cecilia, Moodie, Zoe, Li, Hongli, Russell, Nina, Graham, Barney S., Tomaras, Georgia D., De Rosa, Stephen C., McElrath, M. Juliana
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965084/
https://ncbi.nlm.nih.gov/pubmed/21048953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013579
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