ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot

Chromosome translocations induced by DNA damaging agents, such as ionizing radiation and certain chemotherapies, alter genetic information resulting in malignant transformation. Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a DNA damage signaling regulator, increases the inc...

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Main Authors: Sun, Jiying, Oma, Yukako, Harata, Masahiko, Kono, Kazuteru, Shima, Hiroki, Kinomura, Aiko, Ikura, Tsuyoshi, Suzuki, Hidekazu, Mizutani, Shuki, Kanaar, Roland, Tashiro, Satoshi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965082/
https://ncbi.nlm.nih.gov/pubmed/21048951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013554
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