Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

A balanced deoxyribonucleotide (dNTP) supply is essential for DNA repair. Here, we found that ribonucleotide reductase (RNR) subunits RRM1 and RRM2 accumulated very rapidly at damage sites. RRM1 bound physically to Tip60. Chromatin immunoprecipitation analyses of cells with an I-SceI cassette reveal...

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Detalhes bibliográficos
Main Authors: Niida, Hiroyuki, Katsuno, Yuko, Sengoku, Misuzu, Shimada, Midori, Yukawa, Megumi, Ikura, Masae, Ikura, Tsuyoshi, Kohno, Kazuteru, Shima, Hiroki, Suzuki, Hidekazu, Tashiro, Satoshi, Nakanishi, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816732/
https://ncbi.nlm.nih.gov/pubmed/20159953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1863810
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