SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades mRNAs containing premature stop codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Degradation of PTC-containing mRNAs requires the endonucleoly...

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Bibliographische Detailangaben
Hauptverfasser: Kashima, Isao, Jonas, Stefanie, Jayachandran, Uma, Buchwald, Gretel, Conti, Elena, Lupas, Andrei N., Izaurralde, Elisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2010
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964754/
https://ncbi.nlm.nih.gov/pubmed/20930030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.604610
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