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SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades mRNAs containing premature stop codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Degradation of PTC-containing mRNAs requires the endonucleoly...

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Bibliografske podrobnosti
Main Authors: Kashima, Isao, Jonas, Stefanie, Jayachandran, Uma, Buchwald, Gretel, Conti, Elena, Lupas, Andrei N., Izaurralde, Elisa
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964754/
https://ncbi.nlm.nih.gov/pubmed/20930030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.604610
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