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Δ40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs
Δ40p53 is a transactivation-deficient isoform of the tumor suppressor p53. We discovered that Δ40p53, in addition to being highly expressed in embryonic stem cells (ESCs), is the major p53 isoform during early stages of embryogenesis in the mouse. By altering the dose of Δ40p53 in ESCs, we identifie...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964751/ https://ncbi.nlm.nih.gov/pubmed/21041409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1987810 |
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