Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

OBJECTIVE: Investigating the dynamics of pancreatic β-cell mass is critical for developing strategies to treat both type 1 and type 2 diabetes. p53, a key regulator of the cell cycle and apoptosis, has mostly been a focus of investigation as a tumor suppressor. Although p53 alternative transcripts c...

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Detalhes bibliográficos
Main Authors: Hinault, Charlotte, Kawamori, Dan, Liew, Chong Wee, Maier, Bernhard, Hu, Jiang, Keller, Susanna R., Mirmira, Raghavendra G., Scrable, Heidi, Kulkarni, Rohit N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064094/
https://ncbi.nlm.nih.gov/pubmed/21357466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1379
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