PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM

Amyloid molecules harboring pyroglutamate (pGlu) residue at the N-termini are considered to be important for the development of cerebral amyloidosis such as Alzheimer’s disease and thought to be either spontaneously generated or being catalyzed by glutaminyl cyclase. Familial British dementia (FBD)...

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Autores principales: Tomidokoro, Yasushi, Tamaoka, Akira, Holton, Janice L., Lashley, Tammaryn, Frangione, Blas, Revesz, Tamas, Rostagno, Agueda, Ghiso, Jorge
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964672/
https://ncbi.nlm.nih.gov/pubmed/21037969
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