PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM

Amyloid molecules harboring pyroglutamate (pGlu) residue at the N-termini are considered to be important for the development of cerebral amyloidosis such as Alzheimer’s disease and thought to be either spontaneously generated or being catalyzed by glutaminyl cyclase. Familial British dementia (FBD)...

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Detalhes bibliográficos
Main Authors: Tomidokoro, Yasushi, Tamaoka, Akira, Holton, Janice L., Lashley, Tammaryn, Frangione, Blas, Revesz, Tamas, Rostagno, Agueda, Ghiso, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964672/
https://ncbi.nlm.nih.gov/pubmed/21037969
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