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Azirine Ligation: Fast and Selective Protein Conjugation via Photoinduced Azirine-Alkene Cycloaddition
We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (~ 2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964347/ https://ncbi.nlm.nih.gov/pubmed/20865197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc02863k |
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