TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE)1,2. However, regimens used to treat many such conditions cannot maintain disease control in the majority of SLE patients and more aggressive approaches such as high-dose methylpredni...

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Autori principali: Guiducci, Cristiana, Gong, Mei, Xu, Zhaohui, Gill, Michelle, Chaussabel, Damien, Meeker, Thea, Chan, Jean H., Wright, Tracey, Punaro, Marilynn, Bolland, Silvia, Soumelis, Vassili, Banchereau, Jacques, Coffman, Robert L., Pascual, Virginia, Barrat, Franck J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964153/
https://ncbi.nlm.nih.gov/pubmed/20559388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09102
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