Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents

A series of 2-aryl-4-benzoyl-imidazoles (ABI) was synthesized as a result of structural modifications based on the previous set of 2-aryl-imidazole-4-carboxylic amide (AICA) derivatives and 4-substituted methoxylbenzoyl-aryl-thiazoles (SMART). The average IC(50) of the most active compound (5da) was...

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Hlavní autoři: Chen, Jianjun, Wang, Zhao, Li, Chien-Ming, Lu, Yan, Vaddady, Pavan K., Meibohm, Bernd, Dalton, James T., Miller, Duane D., Li, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964152/
https://ncbi.nlm.nih.gov/pubmed/20919720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100884b
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