Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents

[Image: see text] To block the metabolically labile sites of novel tubulin inhibitors targeting the colchicine binding site based on SMART, ABI, and PAT templates, we have designed, synthesized, and biologically tested three focused sets of new derivatives with modifications at the carbonyl linker,...

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Hauptverfasser: Lu, Yan, Chen, Jianjun, Wang, Jin, Li, Chien-Ming, Ahn, Sunjoo, Barrett, Christina M., Dalton, James T., Li, Wei, Miller, Duane D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161160/
https://ncbi.nlm.nih.gov/pubmed/25122533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500764v
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