Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization

We previously reported the discovery of 2-aryl-4-benzoyl-imidazoles (ABI-I) as potent antiproliferative agents for melanoma. To further understand the structural requirements for the potency of ABI analogs, gain insight in the structure-activity relationships (SAR), and investigate metabolic stabili...

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Main Authors: Chen, Jianjun, Li, Chien-Ming, Wang, Jin, Ahn, Sunjoo, Wang, Zhao, Lu, Yan, Dalton, James T., Miller, Duane D., Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152597/
https://ncbi.nlm.nih.gov/pubmed/21775150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.06.084
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