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Young proteins experience more variable selection pressures than old proteins

It is well known that young proteins tend to experience weaker purifying selection and evolve more quickly than old proteins. Here, we show that, in addition, young proteins tend to experience more variable selection pressures over time than old proteins. We demonstrate this pattern in three indepen...

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Detalhes bibliográficos
Main Authors: Vishnoi, Anchal, Kryazhimskiy, Sergey, Bazykin, Georgii A., Hannenhalli, Sridhar, Plotkin, Joshua B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963820/
https://ncbi.nlm.nih.gov/pubmed/20921233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.109595.110
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