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Directionality in the evolution of influenza A haemagglutinin

The evolution of haemagglutinin (HA), an important influenza virus antigen, has been the subject of intensive research for more than two decades. Many characteristics of HA's sequence evolution are captured by standard Markov chain substitution models. Such models assign equal fitness to all ac...

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Detalhes bibliográficos
Main Authors: Kryazhimskiy, Sergey, Bazykin, Georgii A, Plotkin, Joshua, Dushoff, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603193/
https://ncbi.nlm.nih.gov/pubmed/18647721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2008.0521
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