Par3 Controls Spindle Pole Orientation in Epithelial Cells by aPKC-Mediated Phosphorylation of Pins at the Apical Cortex

BACKGROUND: Formation of epithelial sheets requires that cell division occurs in the plane of the sheet. During mitosis, spindle poles align so the astral microtubules contact the lateral cortex. Confinement of the mammalian Pins protein to the lateral cortex is essential for this process. Defects i...

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Main Authors: Hao, Yi, Du, Quansheng, Chen, Xinyu, Zheng, Zhen, Balsbaugh, Jeremy L., Maitra, Sushmit, Shabanowitz, Jeffrey, Hunt, Donald F., Macara, Ian G.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963683/
https://ncbi.nlm.nih.gov/pubmed/20933426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.09.032
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