Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

OBJECTIVE: The pathogenesis of diabetic nephropathy is complex and involves activation of multiple pathways leading to kidney damage. An important role for altered lipid metabolism via sterol regulatory element binding proteins (SREBPs) has been recently recognized in diabetic kidney disease. Our pr...

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Hlavní autoři: Wang, Xiaoxin X., Jiang, Tao, Shen, Yan, Caldas, Yupanqui, Miyazaki-Anzai, Shinobu, Santamaria, Hannah, Urbanek, Cydney, Solis, Nathaniel, Scherzer, Pnina, Lewis, Linda, Gonzalez, Frank J., Adorini, Luciano, Pruzanski, Mark, Kopp, Jeffrey B., Verlander, Jill W., Levi, Moshe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2010
Témata:
Complications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963551/
https://ncbi.nlm.nih.gov/pubmed/20699418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0019
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