Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

The hepatitis C virus (HCV) NS5b protein is an RNA-dependent RNA polymerase essential for replication of the viral RNA genome. In vitro and presumably in vivo, NS5b initiates RNA synthesis by a de novo mechanism. Different structural elements of NS5b have been reported to participate in RNA synthesi...

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Detalhes bibliográficos
Main Authors: Harrus, Déborah, Ahmed-El-Sayed, Neveen, Simister, Philip C., Miller, Steve, Triconnet, Martine, Hagedorn, Curt H., Mahias, Kathleen, Rey, Félix A., Astier-Gin, Thérèse, Bressanelli, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963421/
https://ncbi.nlm.nih.gov/pubmed/20729191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.151316
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