The Sodium Channel β3-Subunit Induces Multiphasic Gating in Na(V)1.3 and Affects Fast Inactivation via Distinct Intracellular Regions

Electrical excitability in neurons depends on the activity of membrane-bound voltage gated sodium channels (Na(v)) that are assembled from an ion conducting α-subunit and often auxiliary β-subunits. The α-subunit isoform Na(v)1.3 occurs in peripheral neurons together with the Na(v) β3-subunit, both...

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Bibliografiske detaljer
Main Authors: Cusdin, Fiona S., Nietlispach, Daniel, Maman, Joseph, Dale, Timothy J., Powell, Andrew J., Clare, Jeffrey J., Jackson, Antony P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963402/
https://ncbi.nlm.nih.gov/pubmed/20675377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114058
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