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The Sodium Channel β3-Subunit Induces Multiphasic Gating in Na(V)1.3 and Affects Fast Inactivation via Distinct Intracellular Regions
Electrical excitability in neurons depends on the activity of membrane-bound voltage gated sodium channels (Na(v)) that are assembled from an ion conducting α-subunit and often auxiliary β-subunits. The α-subunit isoform Na(v)1.3 occurs in peripheral neurons together with the Na(v) β3-subunit, both...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963402/ https://ncbi.nlm.nih.gov/pubmed/20675377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114058 |
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