Lipid Raft Association and Cholesterol Sensitivity of P2X1-4 Receptors for ATP: CHIMERAS AND POINT MUTANTS IDENTIFY INTRACELLULAR AMINO-TERMINAL RESIDUES INVOLVED IN LIPID REGULATION OF P2X1 RECEPTORS

Cholesterol-rich lipid rafts act as signaling microdomains and can regulate receptor function. We have shown in HEK293 cells recombinant P2X1-4 receptors (ATP-gated ion channels) are expressed in lipid rafts. Localization to flotillin-rich lipid rafts was reduced by the detergent Triton X-100. This...

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Bibliografiska uppgifter
Huvudupphovsmän: Allsopp, Rebecca C., Lalo, Ulyana, Evans, Richard J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Lipids
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963349/
https://ncbi.nlm.nih.gov/pubmed/20699225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.148940
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