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Heat Shock Protein 90 Inhibitors Reduce Trafficking of ATP-gated P2X1 Receptors and Human Platelet Responsiveness

We have used selective inhibitors to determine whether the molecular chaperone heat shock protein 90 (HSP90) has an effect on both recombinant and native human P2X1 receptors. P2X1 receptor currents in HEK293 cells were reduced by ∼70–85% by the selective HSP90 inhibitor geldanamycin (2 μm, 20 min)....

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Detalhes bibliográficos
Main Authors: Lalo, Ulyana, Jones, Sarah, Roberts, Jonathan A., Mahaut-Smith, Martyn P., Evans, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463321/
https://ncbi.nlm.nih.gov/pubmed/22851178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.376566
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