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Engineering splicing factors with designed specificities

Alternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to activate or inhibit the splicing reaction. This regulation is critical for normal gene expression, and dysregulation of splicing is closely associated with human diseases. Here we engineer artifici...

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書目詳細資料
Main Authors: Wang, Yang, Cheong, Cheom-Gil, Hall, Traci M. Tanaka, Wang, Zefeng
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963066/
https://ncbi.nlm.nih.gov/pubmed/19801992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1379
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