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Engineering splicing factors with designed specificities
Alternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to activate or inhibit the splicing reaction. This regulation is critical for normal gene expression, and dysregulation of splicing is closely associated with human diseases. Here we engineer artifici...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963066/ https://ncbi.nlm.nih.gov/pubmed/19801992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1379 |
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