Generation of novel pharmacogenomic candidates in the response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype

OBJECTIVES: Little is known about mechanisms of efficacy of methotrexate (MTX) in childhood arthritis, or genetic influences upon response to MTX. The aims of this study were to use gene expression profiling to identify novel pathways/genes altered by MTX and then investigate these genes for genotyp...

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Détails bibliographiques
Auteurs principaux: Moncrieffe, Halima, Hinks, Anne, Ursu, Simona, Kassoumeri, Laura, Etheridge, Angela, Hubank, Mike, Martin, Paul, Weiler, Tracey, Glass, David N, Thompson, Susan D., Thomson, Wendy, Wedderburn, Lucy R
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963015/
https://ncbi.nlm.nih.gov/pubmed/20827233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32833f2cd0
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