Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis

OBJECTIVES: Methotrexate (MTX) is the mainstay treatment for juvenile idiopathic arthritis (JIA), however approximately 30% of children will fail to respond to the drug. Identification of genetic predictors of response to MTX would be invaluable in developing optimal treatment strategies for JIA. Us...

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Hlavní autoři: Hinks, Anne, Moncrieffe, Halima, Martin, Paul, Ursu, Simona, Lal, Sham, Kassoumeri, Laura, Weiler, Tracey, Glass, David N, Thompson, Susan D, Wedderburn, Lucy R, Thomson, Wendy
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2011
Témata:
Clinical and Epidemiological Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128324/
https://ncbi.nlm.nih.gov/pubmed/21515602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2010.146191
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