Generation of novel pharmacogenomic candidates in the response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype

OBJECTIVES: Little is known about mechanisms of efficacy of methotrexate (MTX) in childhood arthritis, or genetic influences upon response to MTX. The aims of this study were to use gene expression profiling to identify novel pathways/genes altered by MTX and then investigate these genes for genotyp...

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Main Authors: Moncrieffe, Halima, Hinks, Anne, Ursu, Simona, Kassoumeri, Laura, Etheridge, Angela, Hubank, Mike, Martin, Paul, Weiler, Tracey, Glass, David N, Thompson, Susan D., Thomson, Wendy, Wedderburn, Lucy R
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963015/
https://ncbi.nlm.nih.gov/pubmed/20827233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32833f2cd0
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