Prolyl Hydroxylase Domain (PHD) 2 Affects Cell Migration and F-actin Formation via RhoA/Rho-associated Kinase-dependent Cofilin Phosphorylation

Cells are responding to hypoxia via prolyl-4-hydroxylase domain (PHD) enzymes, which are responsible for oxygen-dependent hydroxylation of the hypoxia-inducible factor (HIF)-1α subunit. To gain further insight into PHD function, we generated knockdown cell models for the PHD2 isoform, which is the m...

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Main Authors: Vogel, Sabine, Wottawa, Marieke, Farhat, Katja, Zieseniss, Anke, Schnelle, Moritz, Le-Huu, Sinja, von Ahlen, Melanie, Malz, Cordula, Camenisch, Gieri, Katschinski, Dörthe M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962474/
https://ncbi.nlm.nih.gov/pubmed/20801873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.132985
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