Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions

On a molecular level, cells sense changes in oxygen availability through the PHDs, which regulate the protein stability of the α-subunit of the transcription factor HIF. Especially, PHD3 has been additionally associated with apoptotic cell death. We hypothesized that PHD3 plays a role in cell-fate d...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Swain, Lija, Wottawa, Marieke, Hillemann, Annette, Beneke, Angelika, Odagiri, Haruki, Terada, Kazutoyo, Endo, Motoyoshi, Oike, Yuichi, Farhat, Katja, Katschinski, Dörthe M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2014
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395934/
https://ncbi.nlm.nih.gov/pubmed/24626957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2HI1013-533R
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