Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury

Prolylhydroxylase domain proteins (PHD) are cellular oxygen-sensing molecules that regulate the stability of the α-subunit of the transcription factor hypoxia inducible factor (HIF)-1. HIF-1 affects cardiac development as well as adaptation of the heart toward increased pressure overload or myocardi...

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Hlavní autoři: Hölscher, Marion, Silter, Monique, Krull, Sabine, von Ahlen, Melanie, Hesse, Amke, Schwartz, Peter, Wielockx, Ben, Breier, Georg, Katschinski, Dörthe M., Zieseniss, Anke
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064173/
https://ncbi.nlm.nih.gov/pubmed/21270129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186809
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