An Exceptionally Potent Inducer of Cytoprotective Enzymes: ELUCIDATION OF THE STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1

The Keap1/Nrf2/ARE pathway controls a network of cytoprotective genes that defend against the damaging effects of oxidative and electrophilic stress, and inflammation. Induction of this pathway is a highly effective strategy in combating the risk of cancer and chronic degenerative diseases, includin...

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Dettagli Bibliografici
Autori principali: Dinkova-Kostova, Albena T., Talalay, Paul, Sharkey, John, Zhang, Ying, Holtzclaw, W. David, Wang, Xiu Jun, David, Emilie, Schiavoni, Katherine H., Finlayson, Stewart, Mierke, Dale F., Honda, Tadashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962473/
https://ncbi.nlm.nih.gov/pubmed/20801881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163485
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