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Evolution of Human Calicivirus RNA In Vivo: Accumulation of Mutations in the Protruding P2 Domain of the Capsid Leads to Structural Changes and Possibly a New Phenotype
In the present study we report on evolution of calicivirus RNA from a patient with chronic diarrhea (i.e., lasting >2 years) and viral shedding. Partial sequencing of open reading frame 1 (ORF1) from 12 consecutive isolates revealed shedding of a genogroup II virus with relatively few nucleotide...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC296070/ https://ncbi.nlm.nih.gov/pubmed/14645568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.24.13117-13124.2003 |
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