Evolution of Human Calicivirus RNA In Vivo: Accumulation of Mutations in the Protruding P2 Domain of the Capsid Leads to Structural Changes and Possibly a New Phenotype

In the present study we report on evolution of calicivirus RNA from a patient with chronic diarrhea (i.e., lasting >2 years) and viral shedding. Partial sequencing of open reading frame 1 (ORF1) from 12 consecutive isolates revealed shedding of a genogroup II virus with relatively few nucleotide...

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Detalhes bibliográficos
Main Authors: Nilsson, Mikael, Hedlund, Kjell-Olof, Thorhagen, Margareta, Larson, Göran, Johansen, Kari, Ekspong, Anders, Svensson, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC296070/
https://ncbi.nlm.nih.gov/pubmed/14645568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.24.13117-13124.2003
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