Reduction of Natural Adenovirus Tropism to Mouse Liver by Fiber-Shaft Exchange in Combination with both CAR- and αv Integrin-Binding Ablation

The primary receptor, the coxsackievirus and adenovirus receptor (CAR), and the secondary receptor, αv integrins, are the tropism determinants of adenovirus (Ad) type 5. Inhibition of the interaction of both the fiber with CAR and the penton base with the αv integrin appears to be crucial to the dev...

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Pubblicato in:	J Virol
Autori principali:	Koizumi, Naoya, Mizuguchi, Hiroyuki, Sakurai, Fuminori, Yamaguchi, Teruhide, Watanabe, Yoshiteru, Hayakawa, Takao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Gene Therapy
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296053/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.24.13062-13072.2003
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