Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.

T cell activation involves not only recognition of antigen presented by the MHC, but also nonspecific interactions termed "costimulation." The costimulatory molecules B7-1 and B7-2 are ligands on antigen-presenting cells for the CD28 and CTLA-4 receptors on T cells. Previously, a fusion pr...

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Bibliografiske detaljer
Main Authors: Cross, A H, Girard, T J, Giacoletto, K S, Evans, R J, Keeling, R M, Lin, R F, Trotter, J L, Karr, R W
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC295963/
https://ncbi.nlm.nih.gov/pubmed/7539461
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