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Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes
Sharks are representatives of the earliest vertebrates that possess an immune system utilizing V(D)J recombination to generate antigen receptors. Their antibody repertoire diversity is based in part on a somatic hypermutation process that introduces adjacent nucleotide substitutions of 2-5 bp. We ha...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2959145/ https://ncbi.nlm.nih.gov/pubmed/20921520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000779 |
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