p27(Kip1 )deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process

BACKGROUND: p27 is a cell cycle suppressor gene, whose protein is a negative regulator of cyclin/cdk complexes. p27 is also a potential target of retinoids in cancer prevention studies. In benign prostate hyperplasia (BPH), and in most carcinomas, p27(Kip1 )is down-regulated, suggesting its potentia...

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Bibliografske podrobnosti
Main Authors: Taylor, Winna, Mathias, Amanda, Ali, Arshia, Ke, Hengning, Stoynev, Nikolay, Shilkaitis, Anne, Green, Albert, Kiyokawa, Hiroaki, Christov, Konstantin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958951/
https://ncbi.nlm.nih.gov/pubmed/20932324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-541
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