Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes

In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ proteins to be evolutionarily conserved, with relatively little sequence change over time. Here, we report that while critical domains of th...

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Detalhes bibliográficos
Main Authors: Demogines, Ann, East, Alysia M., Lee, Ji-Hoon, Grossman, Sharon R., Sabeti, Pardis C., Paull, Tanya T., Sawyer, Sara L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958818/
https://ncbi.nlm.nih.gov/pubmed/20975951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001169
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