Prognostic Significance of CDKN2A (p16) Promoter Methylation and Loss of Expression in 902 Colorectal Cancers: Cohort Study and Literature Review

A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation o...

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Main Authors: Shima, Kaori, Nosho, Katsuhiko, Baba, Yoshifumi, Cantor, Mami, Meyerhardt, Jeffrey A., Giovannucci, Edward L., Fuchs, Charles S., Ogino, Shuji
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958235/
https://ncbi.nlm.nih.gov/pubmed/20473920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25432
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